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肌脂蛋白抗體規(guī)格 英文名稱  Anti-SLN/Sarcolipin

中文名稱  肌脂蛋白抗體規(guī)格 

別    名 SARCO_HUMAN; Sarcolipin; SLN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來(lái)源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Rabbit

產(chǎn)品類型   一抗  

研究領(lǐng)域    心 信號(hào)轉(zhuǎn)導(dǎo) 通道蛋白

蛋白分子量  predicted molecular weight: 3.7kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human SLN/Sarcolipin(1-31aa)

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

肌脂蛋白抗體規(guī)格 產(chǎn)品應(yīng)用   ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Sarcolipin is a 31 amino acid integral membrane protein belonging to the sarcolipin family. The gene encoding for the protein maps to chromosome 11q22-q23. SLN, localizing to the sarcoplasmic reticulum, regulates Ca-ATPase activity in skeletal muscle. It associates with calcium ATPase SERCA1 (Sarco(endo)plasmic reticulum Ca2+-ATPases). In muscle tissue, SERCAs are regulated by sarcolipin and another membrane protein, phospholamban (PLN). SLN is expressed in high levels in fast-twitch muscle, which has high expression of SERCA1a, and in lower levels in cardiac muscle. In rats, however, expression of SLN is higher in cardiac muscle than in fast-twitch muscle.

Subunit : Associated with calcium ATPase SERCA1.

Subcellular Location : Sarcoplasmic reticulum membrane; Single-pass membrane protein.

Similarity : Belongs to the sarcolipin family.

Sarcolipin (SLN)是新近發(fā)現(xiàn)存在于肌漿網(wǎng)中的小分子膜蛋白,分子質(zhì)量為3 kD,由31個(gè)氨基酸構(gòu)成，與受磷蛋白(phospholamban,PLB)屬于同一蛋白家族。SLN可抑制肌漿網(wǎng)鈣泵(sarcoplasmic reticulum Ca2+ ATPase,SERCA)活性，降低其與Ca2+的親和力，通過(guò)獨(dú)立或與PLB協(xié)同作用影響SERCA活性，導(dǎo)致細(xì)胞內(nèi)鈣穩(wěn)態(tài)失衡，降低力，從而發(fā)展為。

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