|
| 產(chǎn)地 | 進(jìn)口、國產(chǎn) |
| 品牌 | 上海莼試 |
| 保存條件 | Store at -20 °C |
| 貨號 | CS12163 |
| 應(yīng)用范圍 | WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 |
| CAS編號 | |
| 抗體名 | Anti-SH2D1A/SAP |
| 克隆性 | 是 |
| 靶點(diǎn) | 詳見說明書 |
| 適應(yīng)物種 | 詳見說明書 |
| 形態(tài) | 詳見說明書 |
| 宿主 | 詳見說明書 |
| 亞型 | IgG |
| 標(biāo)識物 | 詳見說明書 |
| 濃度 | 1mg/1ml% |
| 免疫原 | KLH conjugated synthetic peptide derived from human SH2D1A/SAP |
技術(shù)外包服務(wù):
★信號傳導(dǎo)T淋巴細(xì)胞活化相關(guān)蛋白抗體品牌 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測序、載體構(gòu)建等
★蛋白工程：原核、哺乳動物蛋白表達(dá)系統(tǒng)等
★病毒包裝：腺病毒、慢病毒等
★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等
★細(xì)胞工程：細(xì)胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復(fù)、克隆形成)、細(xì)胞培養(yǎng)、細(xì)胞膜制備、穩(wěn)定細(xì)胞株構(gòu)建、細(xì)胞RNAi技術(shù)等等。
實(shí)驗(yàn)流程：
信號傳導(dǎo)T淋巴細(xì)胞活化相關(guān)蛋白抗體品牌 英文名稱 Anti-SH2D1A/SAP
中文名稱 信號傳導(dǎo)T淋巴細(xì)胞活化相關(guān)蛋白抗體品牌
別 名 SH2 domain protein 1A; DSHP; Duncan disease SH2 protein; SAP; Signaling lymphocyte activation molecule associated protein; SLAM associated protein; T cell signal transduction molecule SAP; SH21A_HUMAN.
產(chǎn)品屬性：
濃 度 1mg/1ml
規(guī) 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep
產(chǎn)品類型 一抗
研究領(lǐng)域 心 免疫學(xué) 信號轉(zhuǎn)導(dǎo)
蛋白分子量 predicted molecular weight: 14kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human SH2D1A/SAP
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
信號傳導(dǎo)T淋巴細(xì)胞活化相關(guān)蛋白抗體品牌 產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-?and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4).
Function : Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Subunit : Interacts with NTRK1, NTRK2 and NTRK3 (By similarity). Interacts with CD84, CD244, LY9, SLAMF1 and FYN.
Subcellular Location : Cytoplasmic
Tissue Specificity : Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
DISEASE : Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
Similarity : Contains 1 SH2 domain.
Database links : UniProtKB/Swiss-Prot: O60880.1
全、新、優(yōu)、品、好四大特點(diǎn)：
信號傳導(dǎo)T淋巴細(xì)胞活化相關(guān)蛋白抗體品牌 全：公司提供上萬種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標(biāo)準(zhǔn)品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細(xì)胞等，基本上各種科研所需產(chǎn)品在我司都能找到。
新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。
優(yōu)：產(chǎn)品質(zhì)量好，投訴比較少。
好：我公司具有優(yōu)質(zhì)的技術(shù)團(tuán)隊，產(chǎn)品一旦售出，實(shí)驗(yàn)過程中遇到困難可提供在線技術(shù)咨詢。使您使用產(chǎn)品時沒有任何的后顧之憂。
正在熱銷的相關(guān)產(chǎn)品：
通道修飾因子1 多克隆抗體 SCNM1 Polyclonal Antibody 700/30ul#1540/100ul#2520/200ul
阿米洛利敏感離子通道蛋白1α 多克隆抗體 SCNNA Polyclonal Antibody 700/30ul#1540/100ul#2520/200ul
細(xì)胞色素氧化酶缺失蛋白2 多克隆抗體 SCO2 Polyclonal Antibody 700/30ul#1540/100ul#2520/200ul
清道夫受體B2蛋白 多克隆抗體 SCRB2 Polyclonal Antibody 700/30ul#1540/100ul#2520/200ul
蛋白質(zhì)拼接同源物 多克隆抗體 SCRIB Polyclonal Antibody 700/30ul#1540/100ul#2520/200ul
錨蛋白重復(fù)結(jié)構(gòu)域蛋白11抗體 轉(zhuǎn)錄因子Gli4/鋅指蛋白gli4抗體
磷酸化非受體酪氨酸激酶c-Abl抗體 轉(zhuǎn)錄因子Gli3抗體
溶血磷脂酸?；D(zhuǎn)移酶β抗體 轉(zhuǎn)錄因子Gli2抗體
AFP4b蛋白抗體 轉(zhuǎn)錄因子GATA3結(jié)合蛋白G3B抗體
醛固酮還原酶家族1成員D1抗體 轉(zhuǎn)錄因子EYA1抗體
轉(zhuǎn)錄因子SP5 多克隆抗體 SP5 Polyclonal Antibody 700/30ul#1540/100ul#2520/200ul
轉(zhuǎn)錄因子SP5 多克隆抗體 SP5 Polyclonal Antibody 700/30ul#1540/100ul#2520/200ul
轉(zhuǎn)錄因子SP6 多克隆抗體 SP6 Polyclonal Antibody 700/30ul#1540/100ul#2520/200ul
轉(zhuǎn)錄因子SP7 多克隆抗體 SP7 Polyclonal Antibody 700/30ul#1540/100ul#2520/200ul
絲氨酸蛋白酶抑制蛋白A12 多克隆抗體 SPA12 Polyclonal Antibody 700/30ul#1540/100ul#2520/200ul
白花前胡P. praerupterum Dunn Praeruptorin A 白花前胡甲素 73069-25-7 C22H22O7 ≥98%
10-姜酚10-GingqrolHPLC≥98%;20mg/支
連翹酯苷E Forsythoside E 93675-88-8 20mg HPLC≥98% 連翹酯苷E 93675-88-8
檢查奧美沙坦酯雜質(zhì)混合物100553-200601-20℃，避光50mg
Dexametxasone Phosphate地塞米松酸標(biāo)準(zhǔn)品312-93-6200mg
信號傳導(dǎo)T淋巴細(xì)胞活化相關(guān)蛋白抗體品牌96946-42-8 本碳酸順阿曲庫胺標(biāo)準(zhǔn)品 350mg
澤瀉 Alisma orientalis (Sam.)Juzep. 澤瀉醇B-23-醋酸酯 26575-95-1 C32H50O5 ≥98% 肖酸毛果蕓香減;肖酸匹魯卡品：用于系統(tǒng)適用性試驗(yàn)(Y0000106
Licorisoflavan A 129314-37-0
Related Compound B相關(guān)雜質(zhì)B標(biāo)準(zhǔn)品2011-66-725mg相關(guān)雜質(zhì)B標(biāo)準(zhǔn)品
58-43- HPLC≥98%;20mg 訂購|咨詢
|
|
|
|
