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素A2受體抗體說(shuō)明書(shū) 英文名稱  Anti-TXA2R

中文名稱  素A2受體抗體說(shuō)明書(shū) 

別    名 Thromboxane A2 receptor; Prostanoid TP receptor; TBXA2R; TP receptor; TXA2 R; TXA2R.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來(lái)源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat

產(chǎn)品類型   一抗  

研究領(lǐng)域    心 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞膜受體 G蛋白偶聯(lián)受體

蛋白分子量  predicted molecular weight: 40-55kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Thromboxane A2 receptor

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

素A2受體抗體說(shuō)明書(shū) 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Thromboxane A2 receptor is a member of the G protein-coupled receptor superfamily. It performs an essential role in hemostasis by interacting with thromboxane A2 to induce platelet aggregation. Thromboxane A2 is an arachidonic acid metabolite produced by the action of thromboxane synthase on prostaglandin endoperoxide H(2) (PGH(2)), which results from the enzymatic transformation of arachidonic acid by the cyclooxygenases (COX-1 and COX-2). In humans Thromboxane A2 signals through two distinct Thromboxane A2 receptor isoforms which differ only in their C-terminal tails: alpha form (placenta) and beta form (endothelium). The interaction between Thromboxane A2 receptor and Thromboxane A2 is involved in the pathogenesis of numerous cardiovascular diseases such as atherosclerosis. Consequently, designing Thromboxane A2 receptor antagonists remains of great interest in cardiovascular medicine.

Function : Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

Subunit : Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression.

Subcellular Location : Cell membrane; Multi-pass membrane protein.

Similarity : Belongs to the G-protein coupled receptor 1 family.

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