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脂蛋白磷脂酶A2抗體品牌 英文名稱  Anti-PAFAH/Lp-PLA2

中文名稱  脂蛋白磷脂酶A2抗體品牌 

別    名 PLA2G7; PAFAH; lipoprotein-associated phospholipase A2; Platelet-activating factor acetylhydrolase; PAF acetylhydrolase; PAF 2-acylhydrolase; LDL-associated phospholipase A2; LDL-PLA(2); 2-acetyl-1-alkylglycerophosphocholine esterase; 1-alkyl-2-acetylglycerophosphocholine esterase; PAFA_HUMAN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog

產(chǎn)品類型   一抗  

研究領(lǐng)域    心 激酶和磷酸酶

蛋白分子量  predicted molecular weight: 48kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from humna PAFAH C-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

脂蛋白磷脂酶A2抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl -sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.

Function : Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Subcellular Location : Secreted, extracellular space.

Tissue Specificity : Plasma.

Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Atopic hypersensitivity (ATOPY) [MIM:147050]: A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity : Belongs to the AB hydrolase superfamily. Lipase family.

Database links : UniProtKB/Swiss-Prot: Q13093.1

脂蛋白相關(guān)磷脂A2（Lp-PLA2）也稱血漿血小板激活因子乙酰水解酶，是介導(dǎo)氧化引起和的一個關(guān)鍵性酶。

脂蛋白相關(guān)磷脂酶A2是磷脂酶A2超家族的一個成員,由成熟的巨噬細(xì)胞和淋巴細(xì)胞合成和分泌,主要與結(jié)合,能水解上的氧化卵磷脂,生成促炎物質(zhì)溶血卵磷脂和氧化型游離脂肪酸,促進(jìn)形成,經(jīng)研究認(rèn)為：抑制脂蛋白相關(guān)磷脂酶A2活性可能有*的效應(yīng)。

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