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抑制素/抑制因子抗體規(guī)格 英文名稱  Anti-Prohibitin

中文名稱  抑制素/抑制因子抗體規(guī)格 

別    名 PHB; prohibitin; PHB1; Prohibitin - Mitochondrial Marker; PHB_HUMAN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Horse

產(chǎn)品類型   一抗  

研究領(lǐng)域     細(xì)胞生物 染色質(zhì)和核信號(hào) 細(xì)胞凋亡 細(xì)胞類型標(biāo)志物

蛋白分子量  predicted molecular weight: 30kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Prohibitin C-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

抑制素/抑制因子抗體規(guī)格 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.

Function : Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

Subunit : Interacts with PHB2. Interacts with STOML2.

Subcellular Location : Mitochondrion inner membrane (By similarity).

Similarity : Belongs to the prohibitin family.

Database links : UniProtKB/Swiss-Prot: P35232.1

Prohibitin(phb)基因是一種有效的抑制基因，廣泛分布于不同種屬的各種生物細(xì)胞中，它所編碼的產(chǎn)物Prohibitin(PHB)蛋白結(jié)構(gòu)保守，既存在于線粒體內(nèi)膜上，發(fā)揮分子伴侶作用，也存在于細(xì)胞核內(nèi)，具有負(fù)性轉(zhuǎn)錄調(diào)控作用，因而對(duì)、生長、分化、衰老以及凋亡等諸多方面發(fā)揮 著重要的調(diào)控作用，可能與某些和退行性疾病的發(fā)生有關(guān)。

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